Preheat oven to 250 degrees and line two baking sheets with foil or parchment.
Melt butter and pour into a bowl with honey, Dijon, garlic and onion powders and dried mustard. Whisk until completely blended.
Pour half of the sauce and half of the pretzels into a gallon zip top bag. Shake until the pretzels are well coated.
Spread onto the prepared baking sheet. Repeat with the remaining sauce and pretzels and pour onto the second baking sheet.
Bake for 45 min to an hour until the ends of the pretzels begin to brown. Stir every 10-15 minutes.
Stir periodically as they cool to keep them from sticking.
Store in a tightly covered container or zip top bag.